Difluorocarboxyfluorescein Azide, 6-isomer

Unit Size
Price (USD)
Cat.#: 1225-1
Unit size: 1 mg
in stock
Cat.#: 1225-5
Unit size: 5 mg
in stock
Cat.#: 1225-25
Unit size: 25 mg
in stock
Cat.#: 1225-100
Unit size: 100 mg
in stock

2′, 7′-Difluorocarboxyfluorescein Azide, 6-isomer (also under Oregon Green 488 Azide (Oregon Green™ 6-Carboxamido-(6-Azidohexanyl), Triethylammonium Salt), 6-isomer name) is a bright, green-fluorescent azide-activated probe that reacts with terminal alkynes via a copper-catalyzed click reaction (CuAAC). It also reacts with strained cyclooctyne via a copper-free click chemistry reaction to form a stable triazole and does not require Cu-catalyst or elevated temperatures.

2′,7′-Difluorocarboxyfluorescein fluorinated analog of fluorescein that overcomes some of the key limitations of fluorescein, including greater photostability and a lower pKa (pKa ~ 4.7 versus 6.4 for fluorescein), making its fluorescence essentially pH insensitive in the physiological pH range.

Difluorocarboxyfluorescein Azide, 6-isomer is structurally identical to Invitrogen’s Oregon Green® 488 Azide, isomer 6

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Alkynes, cyclooctynes
Abs/Em Maxima
496/524 nm
Extinction coefficient
78,000 cm-1M-1
Spectrally similar dyes
Alexa Fluor® 488, DyLight® 488, Fluorescein, Oregon Green 488
Molecular weight
Storage conditions
Shipping conditions
Ambient temperature

Alexa Fluor® Dyes and Oregon Green Dye is a registered trademark of Invitrogen, part of Thermo Fisher Scientific. Fluoroprobes is not affiliated with or endorsed by Thermo Fisher Scientific. AF Dyes are GENERIC versions of Alexa Fluor® Dyes and ARE NOT manufactures, distributed, or affiliated in any way with Thermo Fisher Scientific.